Linaclotide (L-Tyrosine) CAS 851199-59-2 CAS 851199-60-5 (Acetate salt) CAS 1863191-43-8 (TFA salt)
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- 09/12/2024 12:12
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Linaclotide (L-Tyrosine) CAS 851199-59-2 CAS 851199-60-5 (Acetate salt) CAS 1863191-43-8 (TFA salt)
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Linaclotide
CAS NO.: 851199-59-2
Targets Guanylate Cyclase
Molecular Formula C59H79N15O21S6
Molecular Weight 1526.74
Purity ≥95%
Related CAS 851199-60-5 (acetate salt) 1863191-43-8 (TFA salt)
Appearance White Solid
Synonyms
Constella; Linzess; L-Tyrosine, L-cysteinyl-L-cysteinyl-L-α-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparaginyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-, cyclic (1→6),(2→10),(5→13)-tris(disulfide); L-cysteinyl-L-cysteinyl-L-α-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparagyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonyl-glycyl-L-cysteinyl-L-tyrosine (1->6),(2->10),(5->13)-tris(disulfide); H-Cys-Cys-Glu-Tyr-Cys-Cys-Asn-Pro-Ala-Cys-Thr-Gly-Cys-Tyr-OH (Disulfide bridge: Cys1-Cys6, Cys2-Cys10, Cys5-Cys13)
Solubility Soluble in DMSO (Slightly, Heated), Methanol (Slightly, Heated), Water (Slightly, Heated)
Storage Store at -20°C
Linaclotide is a peptide agonist of guanylate cyclase 2C that is undergoing clinical trials for use in treating abdominal pain in patients with irritable bowel syndrome (IBS) accompanied by constipation. The drug also has promising outlooks for the treatment of gastroparesis, ulcerative colitis, chronic intestinal pseudo-obstruction (CIPO), and inertia coli as well.
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Նախընտրելի տարիք
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Նկարագիր
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Linaclotide
CAS NO.: 851199-59-2
Targets Guanylate Cyclase
Molecular Formula C59H79N15O21S6
Molecular Weight 1526.74
Purity ≥95%
Related CAS 851199-60-5 (acetate salt) 1863191-43-8 (TFA salt)
Appearance White Solid
Synonyms
Constella; Linzess; L-Tyrosine, L-cysteinyl-L-cysteinyl-L-α-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparaginyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-, cyclic (1→6),(2→10),(5→13)-tris(disulfide); L-cysteinyl-L-cysteinyl-L-α-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparagyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonyl-glycyl-L-cysteinyl-L-tyrosine (1->6),(2->10),(5->13)-tris(disulfide); H-Cys-Cys-Glu-Tyr-Cys-Cys-Asn-Pro-Ala-Cys-Thr-Gly-Cys-Tyr-OH (Disulfide bridge: Cys1-Cys6, Cys2-Cys10, Cys5-Cys13)
Solubility Soluble in DMSO (Slightly, Heated), Methanol (Slightly, Heated), Water (Slightly, Heated)
Storage Store at -20°C
Linaclotide is a peptide agonist of guanylate cyclase 2C that is undergoing clinical trials for use in treating abdominal pain in patients with irritable bowel syndrome (IBS) accompanied by constipation. The drug also has promising outlooks for the treatment of gastroparesis, ulcerative colitis, chronic intestinal pseudo-obstruction (CIPO), and inertia coli as well.
